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Consumer Medicine Information (CMI)

D-REGLIS
 •    Ingredients and active components
D-Reglis tablet contains at least 380 mg standardized dry extract of liquorice (Glycyrrhiza glabra L.). The level of glycyrrhizinic acid in the extract is reduced to less than 3%.
 

•    What D-REGLIS is used for 

• Peptic and duodenal ulcers
• Acid hypersecretion
• Flatulence
• Zollinger-Ellison Syndrome
• Prevention of peptic ulcers due to usage of NSAIDs

•    How D-REGLIS works 
The therapeutic effect of liquorice is as a result of its various flavonoids. Flavonoids in this medicine prevent metabolism of prostaglandins which increase the level of prostaglandins in the upper digestive tract.  Prostaglandins, on the one hand, decrease acid secretion from parietal cells and, on the other hand, provide a protective coating for the digestive tract mucosal cells by increasing excretion of mucosa and bicarbonate. These compounds also increase the production of gastric glycoprotein.
Liquiritigenin and isoliquiritigenin are two other components in the tablets which have papaverine- like spasmolytic effects in the gastrointestinal track. Due to the elimination of glycyrrhizin, the mineralocorticoid and glucocorticoid side effects of liquorice has been minimized in this formulation.
 
D-Reglis tablet also contains calcium carbonate which increases the antacid effect of this medicine.

•    Before you use D-REGLIS
‎When NOT to take it 

• Children younger than 6 years,
• Cardiovascular diseases, hypertension, chronic hepatitis, liver cirrhosis, liver cholestasis diseases, gall bladder inflammation, severe renal disorders, hyper-secretion of adrenal glands and Diabetes Mellitus.

Use during Pregnancy and Lactation
NOT to be taken during pregnancy and lactation.
 
 
•    Taking D-REGLIS
‎How and when to ‎take it 

• 2 tablets, 3 times a day before each meal.
• For treatment of duodenal ulcer: up to 6 times a day can be used.

‎How long to take it 
In case of any physician recommendation, continue taking it until the visible symptoms of deficiency have improved.
‎What to do if you miss a dose 
If you miss a dose of D-Reglis, try to take it as soon as remember if it’s almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of it at the same time.

•    While you are taking D-REGLIS
‎Things you ‎must not do ‎ 
Concurrent use of D-Reglis with Furosemide, antiarrhythmic and thiazide diuretics are not recommended.
‎Things to be careful of‎ 
Take precautions if you use this medicine concurrently with corticosteroid and hormonal drugs.
 

•    Side effects 
Pure extract of liquorice contains high levels of glycyrrhizinic acid and can cause mineralocorticoid reactions in the form of water and sodium retention, potassium excretion and increase in blood pressure. However, these adverse reactions are not often seen with D-Reglis, as the level of glycyrrhizinic in the liquorice extract is lowered from 30% to 3% through hydrolysis. If this medicine is used over long periods (more than 6 consecutive months), it may cause hypertension; however, having two drug-free weeks would alleviate the above-mentioned reactions.
 

•    After taking it
‎Storage 

• Store in a dry place, keep away from direct sunlight and below 25 °C.
• Keep out of sight and the reach of children.

‎Disposal 
Do not put into sewer lines. Dispose in the everyday rubbish bin.‎
 

•    The Product ‎ 
‎What D-REGLIS looks like 
Dosage Form: Tablet
Packaging: 10 blisters each one containing 10 tablets inside cardboard package; patient information leaflet inside.

‎Manufacturer 
This product is made from high quality local and imported herbs organically planted and ‎harvested. It has been formulated by ‎Iran Darouk Pharmaceuticals.‎