Sena-Gragh

Consumer Medicine Information (CMI)

SENA-GRAPH
 •    Ingredients and active components
Sena-Graph syrup is made from standardized extract of Senna leaves (Cassia angustifolia L.). Each 100 ml of Sena-Graph syrup contains 995 mg standardized dry extract.
 

•    What SENA-GRAPH is used for 
Complete evacuation of colon before Radiography, Colonoscopy or Surgery.
 

•    How SENA-GRAPH works 
The healing effect of Senna is due to its Anthraquinone (Hydroxy Anthracene) glycosides (especially A&B Sennosides). Sennosides A & B are metabolized by the bacteria in the colon and are converted to active metabolites such as Rheinanthron.
 Rheinanthron:

1. Increases the synthesis and secretion of prostaglandins especially PGE2 in the colon. So it causes:

• stimulation of peristaltic contractions, inhibition of local contraction of muscles of the large intestine,

• Secretion of fluids and electrolytes into the intestinal lumen (increasing the secretion of mucosa and active chlorides) and helps defecation.

1. Reduces intestinal fluid absorption.

Furthermore, Senna contains Histamine and 5-Hydroxy Triptamine (5-HT) that have purgative effects.
 

•    Before you take SENA-GRAPH
‎When NOT to take it 

• Children under 6 years old,
• Intestinal obstruction or stenosis,
• Colic, Rectal bleeding with unknown etiology,
• Appendicitis,
• Anal prolapse and hemorrhoids.

Use during Pregnancy and Lactation
NOT to be taken during pregnancy and lactation.
 

•    Taking SENA-GRAPH
‎How and when to ‎take it 

• Body weight: less than 60 Kg: 1 ml syrup per Kg body weight,
• Body weight: 60Kg or over: the whole bottle should be used.

The day before radiography or sugary, (about from 2pm to 4pm) along with 6-8 glasses of water or more.
‎
How long to take it 
In case of any physician recommendation, this product is a single dose.

‎What to do if you miss a dose 
In case of any physician recommendation, this product is a single dose.
 

•    While you are taking SENA-GRAPH
‎Things you must do‎ 
It is recommended to get the best result for complete GI (Gastro-Intestinal) evacuating, drink at least 1 glass of water every hour. This helps soften the stool and evacuating easily and prevent water loss also.
‎
Things you ‎must not do ‎ 
Do not exceed the recommended dose and note that not to take more than one dose in a 24-hour period

‎Things to be careful of‎ 

• Products containing Senna interact with blood potassium lowering drugs such as thiazide diuretics, adrenocorticosteroids, liquorice, cardiac glycosides, antiarrhythmic agents and their concomitant use may cause cardiac and nerve-muscle disorders.
• Sena-Graph syrup prevents absorption of estrogen and decreases its serum level.
• Indomethacin and Nifedipine decreases the efficacy of Sena-Graph syrup.
• It may interact with diagnostic laboratory tests, (such as measurement of urine urobilinogen and estrogen measurement by Cooper method).
• Sena-Graph syrup may change urine color to red if urine is alkaline and to brown when urine is acidic.

 
•    Side effects 
Except diarrhea, stomach cramps and tenesmus (which are natural side effects of this medicine), no special adverse effects have been reported.
 

•    After taking it
‎Storage 

• Store below 25°C, keep away from direct sunlight and avoid freezing.
• Keep out of sight and reach of children.

‎Disposal 
Do not put into sewer lines. Dispose in the everyday rubbish bin.‎

•    The Product ‎ 
‎What SENA-GRAPH looks like 
Dosage Form: Syrup
Packaging: 60ml, pharmaceutical amber glass bottle, in cardboard box, sachet, and patient information leaflet inside.

‎Manufacturer 
This product is made from high quality local and imported herbs organically planted and ‎harvested. It has been formulated by ‎Iran Darouk Pharmaceuticals.‎